Title: Relation between bronchial asthma and parasitic (nematodes) infection in egyptian children
Presenter: Youssef Habib
BACKGROUND: Among the many factors influencing the prevalence of asthma in developing countries from the tropics are geo-helminthic infections.
AIMS: This work aims to study the relation between bronchial asthma and parasitic infestation in Egyptian children.
PATIENTS AND METHODS: A cross-section, analytical study design was chosen to perform this research on 100 school aged children. All children were interviewed and examined clinically and laboratory.
RESULTS: Statistically significantly Negative correlations were found between blood level of IgE and FEV1% of predicted in patients with bronchial asthma as well as patients with parasitic infestation with r=-0.381, -0.325 at p=0.006, 0.021 respectively.Inverse relationship was found between blood level of IgE and FEV1/FVC% in patients with parasitic infestation with r= -0.358 with statistical significant difference at p=0.011.
CONCLUSIONS: 86%of patients with bronchial asthma lived in urban areas, while 64% of patients with parasitic infestation lived in rural areas.
Title: The Purpose of Temperature of Fever
Presenter: Yacob Mathai
When the disease becomes threat to life or organs blood circulation decreases, Temperature of fever will emerges to increase prevailing blood circulation. And it acts as a protective covering of the body to sustain life.
When blood flow decrease to brain, the patient becomes fainted-delirious .If we try to decreases temperature of fever, the blood circulation will further reduced. Blood circulation never increases without temperature increase. Delirious can never be cured without increase in blood circulation.
The temperature of fever is not a surplus temperature or it is not to be eliminated from the body. During fever, our body temperature increases like a brooding hen`s increased body temperature.
The actual treatment to fever is to increase blood circulation. Two ways to increase blood circulation.
1. Never allow body temperature to lose
2. Apply heat from outside to the body. When the temperature produced by body due to fever and heat which we applied on the body combines together, the blood circulation increases.
Then body will stop to produce heat to increase blood circulation. And body will get extra heat from outside without any usage of energy.
How can we prove that the temperature of fever is to increase blood circulation?
If we ask any type of question related to fever by assuming that the temperature of fever is to increase blood circulation we will get a clear answer. If avoid or evade from this definition we will never get proper answer to even a single question
If we do any type of treatment by assuming that the temperature of fever is to increase blood circulation , the body will accept, at the same time body will resist whatever treatment to decrease blood circulation.
No further evidence is required to prove the temperature of fever is to increase blood circulation.
Title: During fever, why our body acts against Facts of Physics?
Presenter: Yacob Mathai
According to the facts of physics, if temperature increases, thermal expansion of an object is positive it will expand and with decrease of temperature it will shrink. Pressure will increase due to increase of temperature.
On the contrary, during fever we can see blood vessels and skin are shrunk, pressure decreases, body shivers, sleep increases, motion decreases, inflammation increases, body pain increases, blood circulation decreases, dislike cold substances etc…
In fever, the firing rate of Warm sensitive neurons decreases, and the firing rate of Cold sensitive neurons increases.
At the same time if we apply hotness from outside by thermal bag or if we drink hot water, our body acts according to the Facts of Physics- increase of temperature pressure will also increase, expands blood vessels and skin, body sweats, motion will increase , inflammation will decrease , body pain will decrease, blood circulation will increase, like cold substances etc..
During fever, why our body acts against Facts of Physics? when disease increases, pressure and temperature will decrease. Blood circulation will decrease due to decrease of pressure. If the essential temperature of the body is going out, essential temperature and pressure will further decrease. This will further endanger the life or action of organ.
when disease increase, it is the sensible and discreet action of brain that tends to act against facts of physics to sustain life or protect organ .There is no way other than this for a sensible and discreet brain to protect the life or organ.
We will get a clear answer if we find out the purpose of fever, sensible and discreet action of brain . No medical books clarify this1
During fever, if the temperature of fever is not a surplus temperature or if it is not suppose to be eliminated from the body, the shrinking of skin and blood vessels, shivering of body, dislike towards cold substances etc are a protective covering of the body to increase blood circulation to important organs of the body it is against the facts of physics.
Title: Bio gene marker expression in gingival hyperplasia due to Cyclosporine and Phenytoin
Presenter: Surena Vahabi
Background: Since the cellular mechanisms behind the gingival overgrowth has remained unknown especially in pediatrics, the aim of this study was to investigate the effect of CSA and PHT on the bio gene marker expression and compare it among adults and pediatrics.
Methods: Gingival fibroblasts which had been harvested from adults and pediatrics with normal gingiva were incubated with CSA and PHT, and then cultured for 48 hours. MMP (1 , 2), TIMP, Col , Eln, Lysyl, Cat L, B and mRNA level in culture were determined by reverse transcription polymerase chain reaction (RT-PCR), amount of TGFB and EGF were assessed by enzyme-linked immunosorbent assay(ELISA). The alpha error level was set at 0.05 for statistical significance.
Results: CSA and PHT stimulated the TGFB and CATB productions and inhibited expression of MMP1 by fibroblasts. CSA suppressed TIMP in pediatrics but PHT stimulated its expression. In adults, both CSA and PHT increased TGFB, Lysyl and EGF level. CSA reduced Eln level whereas PHT stimulated its level. PHT increased the CAT B level when CSA inhibited TIMP expression
Discussion: It seems that in pediatrics MMP1/TIMP system and in adults Lysyl/Eln pathway play an important role in impaired collagen metabolism.
Title: Transient tachypnea of newborn (TTN)
Presenter: Tarek Kotb
Statement of the problem : TTN is a very common disease but often presents a diagnostic and therapeutic dilemma for the clinicians .
Neonates who are presenting with respiratory distress had a lot of differential diagnosis including respiratory distress syndrome, transient tachypnea of newborn ,air leak syndrome , sepsis , congenital pneumonia , meconium aspiration , PPHN , congenital diaphragmatic hernia ,congenital heart disease , metabolic disorders and malformations.
The purpose of the presentation is to answer a key question ….
Is the diagnosis of Transient tachypnea of new born is still the diagnosis of exclusion ? also to understand the pathophysiology of TTN to identify risk factors ,clinical signs and symptoms and to discuss the radiologic findings in TTN ,
Some answers we should know about the pathophysiology and how fluids are cleared from the newborn lung.
A pathognomonic signs which is the double lung point a sign which will be evidenced by ultrasound chest which is a non-invasive bed side test which can give yoy the clue for diagnosis of transient tachypnnea of newborn,
Also we will demonstrate when you should consider other diagnosis rather than TTN
Conclusion and significance : It can be challenging to diagnose and provide optimal
treatment . for transient tachypnea of the newborn. Ultrasound chest provide a non invasive test bed side can give the clue for many diseases.
Well trained neonatologist for ultrasound chest will improve the care in neonatal intensive care units.
Title: An approach towards promoting Iranian caregivers’ knowledge on Early Childhood Development
Presenter: Elham Habibi
Introduction: According to the WHO, parents need to be informed about Early Childhood Development (ECD). Different methods of parents’ education include group-based, face-to-face, book, booklet, web-based, technology-based, and mobile learning using laptops, tablets, and cell phones. Paying attention to caregivers’ attitudes is the first step to their education. The objectives of this study were to determine parental education requirements and the best approach towards promoting caregivers` knowledge about ECD, from the perspective of the Iranian main child caregivers.
Methods: A qualitative approach with directional content analysis method was used. Participants were selected through purposive sampling. Thirty-one child-caregivers participated in 5 individual interviews and 5 focus group discussions (FGDs). Participants were parents and grandparents that had less than the 36-month child (grandchild) and kindergarten staffs. Four criteria namely: validity, transferability, reliability, and verifiability were used to validate data.
Results: According to the perspective of participants, two main themes were requirements for parent education (educators, educational content, time, place) and approach to educate child caregivers (mobile learning, group and face-to-face education, electronic learning, media, physical resources), totally 98 sub-themes. Finally, the best approach to educate child caregivers was a multi-model approach includes group or face-to-face education with mobile learning.
Discussion: Participants suggested a multi-model approach based on traditional and modern technological methods, especially mobile learning (smartphone). They believed that the educational approach should be flexible and selectable, so caregivers can choose an appropriate individual method.
Conclusion: It seems that the multi-model approach is appropriate to promote Iranian parent or caregivers` knowledge.
Title: Physiological Expression of HLA-G during Pregnancy and Neonatal Period
Presenter: Marcos Roberto Tovani Palone
Human leukocyte antigen (HLA)-G is a nonclassical class I major histocompatibility complex molecule, which has been the target of important studies around the world. Such molecule may exert important tolerogenic functions, both in pregnancy and transplantation. Its discovery was in 1987, when a restricted pattern of HLA-G protein expression (that includes mainly the placental extravillous cytotrophoblast cells in direct contact with maternal tissues) was initially described. Besides, it is known that this protein is also expressed by amnion epithelial cells, erythroid and endotelial cells of fetal blood vessels in the placenta. However, although several scientific evidences have suggested that HLA-G plays a role in protection of the semiallogeneic human fetus by the maternal tolerance, there is not yet a clear consensus on this. It should also be highlighted that HLA-G protein expression in other fetal tissues as well as from of neonates is an understudied subject matter. Thus, any new knowledge regarding to this topic may be essential for better understanding the participation of this protein during the physiological gestation and neonatal period. In this sense, this presentation aims to present the surprising findings of my current study. Such novelties, undoubtedly, will lead researchers to rethink about the gestation mechanism and possibly will result in advances in the fields of pediatrics and neonatology.